Bed & Breakfast

78 N Main St, Ste. Genevieve, MO

Step back in time at Missouri’s oldest continuously operating bed and breakfast, nestled in the heart of the state’s oldest permanent European settlement. Built in 1848, this elegant three-story Federal-style mansion offers beautifully themed rooms adorned with period antiques and private baths. Guests can relax in peaceful outdoor gardens or walk to nearby French colonial historic sites, museums, and local wineries before enjoying a phenomenal, farm-fresh breakfast.

Part of our guide to independent stays in Missouri.